Robot wire harness design plays a critical role in ensuring the reliability and lifespan of modern automation systems. Unlike static cable assemblies, robotic applications require harnesses that can withstand continuous torsion, repeated bending, and long-term operation within drag chains. This article explores key design considerations including torsion resistance, dynamic bend radius control, and drag chain optimization. It also highlights common failure risks and practical strategies to improve cable durability, routing stability, and maintenance efficiency. By addressing mechanical stress and motion dynamics early in the design phase, engineers can significantly extend service life and enhance overall system performance.